Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3

Osteoarthritis is a common degenerative joint disease for which no disease-modifying drugs are currently available. Attempts to treat the disease with small molecule inhibitors of the metalloproteinases that degrade the cartilage matrix have been hampered by a lack of specificity. We aimed to inhibi...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Chanalaris, Anastasios, Doherty, Christine, Marsden, Brian D., Bambridge, Gabriel, Wren, Stephen P., Nagase, Hideaki, Troeberg, Linda
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5588548/
https://ncbi.nlm.nih.gov/pubmed/28798097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.109397
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