Mettl3-mediated m(6)A regulates spermatogonial differentiation and meiosis initiation

METTL3 catalyzes the formation of N(6)-methyl-adenosine (m(6)A) which has important roles in regulating various biological processes. However, the in vivo function of Mettl3 remains largely unknown in mammals. Here we generated germ cell-specific Mettl3 knockout mice and demonstrated that Mettl3 was...

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Dettagli Bibliografici
Pubblicato in:Cell Res
Autori principali: Xu, Kai, Yang, Ying, Feng, Gui-Hai, Sun, Bao-Fa, Chen, Jun-Qing, Li, Yu-Fei, Chen, Yu-Sheng, Zhang, Xin-Xin, Wang, Chen-Xin, Jiang, Li-Yuan, Liu, Chao, Zhang, Ze-Yu, Wang, Xiu-Jie, Zhou, Qi, Yang, Yun-Gui, Li, Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587845/
https://ncbi.nlm.nih.gov/pubmed/28809392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.100
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