The activation of α(2)-adrenergic receptor in the spinal cord lowers sepsis-induced mortality

The effect of clonidine administered intrathecally (i.t.) on the mortality and the blood glucose level induced by sepsis was examined in mice. To produce sepsis, the mixture of D-galactosamine (GaLN; 0.6 g/10 ml)/lipopolysaccharide (LPS; 27 µg/27 µl) was treated intraperitoneally (i.p.). The i.t. pr...

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Vydáno v:Korean J Physiol Pharmacol
Hlavní autoři: Kim, Sung-Su, Park, Soo-Hyun, Lee, Jae-Ryung, Jung, Jun-Sub, Suh, Hong-Won
Médium: Artigo
Jazyk:Inglês
Vydáno: The Korean Physiological Society and The Korean Society of Pharmacology 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587600/
https://ncbi.nlm.nih.gov/pubmed/28883754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2017.21.5.495
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