Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients

The oncogenic mechanisms of overnutrition, a confirmed independent cancer risk factor, remain poorly understood. Herein, we report that enoyl-CoA hydratase-1 (ECHS1), the enzyme involved in the oxidation of fatty acids (FAs) and branched-chain amino acids (BCAAs), senses nutrients and promotes mTOR...

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Published in:Nat Commun
Main Authors: Zhang, Ya-Kun, Qu, Yuan-Yuan, Lin, Yan, Wu, Xiao-Hui, Chen, Hou-Zao, Wang, Xu, Zhou, Kai-Qiang, Wei, Yun, Guo, Fushen, Yao, Cui-Fang, He, Xia-Di, Liu, Li-Xia, Yang, Chen, Guan, Zong-Yuan, Wang, Shi-Dong, Zhao, Jianyuan, Liu, De-Pei, Zhao, Shi-Min, Xu, Wei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587591/
https://ncbi.nlm.nih.gov/pubmed/28878358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00489-5
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