Targeting Bacterial Cardiolipin Enriched Microdomains: An Antimicrobial Strategy Used by Amphiphilic Aminoglycoside Antibiotics

Some bacterial proteins involved in cell division and oxidative phosphorylation are tightly bound to cardiolipin. Cardiolipin is a non-bilayer anionic phospholipid found in bacterial inner membrane. It forms lipid microdomains located at the cell poles and division plane. Mechanisms by which microdo...

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Bibliographic Details
Published in:Sci Rep
Main Authors: El Khoury, Micheline, Swain, Jitendriya, Sautrey, Guillaume, Zimmermann, Louis, Van Der Smissen, Patrick, Décout, Jean-Luc, Mingeot-Leclercq, Marie-Paule
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587548/
https://ncbi.nlm.nih.gov/pubmed/28878347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10543-3
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