RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury

Traumatic brain injury (TBI) causes extensive neural damage, often resulting in long-term cognitive impairments. Unfortunately, effective treatments for TBI remain elusive. The RhoA-ROCK signaling pathway is a potential therapeutic target since it is activated by TBI and can promote the retraction o...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mulherkar, Shalaka, Firozi, Karen, Huang, Wei, Uddin, Mohammad Danish, Grill, Raymond J., Costa-Mattioli, Mauro, Robertson, Claudia, Tolias, Kimberley F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587534/
https://ncbi.nlm.nih.gov/pubmed/28878396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11113-3
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