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Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus

The aggregation mechanism of phosphorylated tau is an important therapeutic target for tauopathies, including Alzheimer’s disease, although the mechanism by which aggregation occurs is still unknown. Because the phosphorylation process of tau is involved in the trafficking of AMPA receptors, which a...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Kimura, Tetsuya, Suzuki, Mamiko, Akagi, Takumi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5586024/
https://ncbi.nlm.nih.gov/pubmed/28874186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0469-x
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