Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica

Neuromyelitis optica (NMO) is an inflammatory disorder mediated by antibodies to aquaporin-4 (AQP4) with prominent blood-brain barrier (BBB) breakdown in the acute phase of the disease. Anti-AQP4 antibodies are produced mainly in the periphery, yet they target the astrocyte perivascular end feet beh...

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Bibliografske podrobnosti
izdano v:Sci Transl Med
Main Authors: Shimizu, Fumitaka, Schaller, Kristin L., Owens, Gregory P., Cotleur, Anne C., Kellner, Debra, Takeshita, Yukio, Obermeier, Birgit, Kryzer, Thomas J., Sano, Yasuteru, Kanda, Takashi, Lennon, Vanda A., Ransohoff, Richard M., Bennett, Jeffrey L.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585784/
https://ncbi.nlm.nih.gov/pubmed/28679661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aai9111
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