Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica

Neuromyelitis optica (NMO) is an inflammatory disorder mediated by antibodies to aquaporin-4 (AQP4) with prominent blood-brain barrier (BBB) breakdown in the acute phase of the disease. Anti-AQP4 antibodies are produced mainly in the periphery, yet they target the astrocyte perivascular end feet beh...

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Pubblicato in:Sci Transl Med
Autori principali: Shimizu, Fumitaka, Schaller, Kristin L., Owens, Gregory P., Cotleur, Anne C., Kellner, Debra, Takeshita, Yukio, Obermeier, Birgit, Kryzer, Thomas J., Sano, Yasuteru, Kanda, Takashi, Lennon, Vanda A., Ransohoff, Richard M., Bennett, Jeffrey L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585784/
https://ncbi.nlm.nih.gov/pubmed/28679661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aai9111
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