Suppression of gene amplification and chromosomal DNA integration by the DNA mismatch repair system

Mismatch repair (MMR)-deficient cells are shown to produce >15-fold more methotrexate-resistant colonies than MMR normal cells. The increased resistance to methotrexate is primarily due to gene amplification since all the resistant clones contain double-minute chromosomes and increased copy numbers...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Lin, Ching-Tai, Lyu, Yi Lisa, Xiao, Hai, Lin, Wei-Hsin, Whang-Peng, Jacqueline
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55855/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11504867/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.16.3304
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