A functional IFN-λ4-generating DNA polymorphism could protect older asthmatic women from aeroallergen sensitization and associate with clinical features of asthma

Lambda interferons (IFNLs) have immunomodulatory functions at epithelial barrier surfaces. IFN-λ4, a recent member of this family is expressed only in a subset of the population due to a frameshift-causing DNA polymorphism rs368234815. We examined the association of this polymorphism with atopy (aer...

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Udgivet i:Sci Rep
Main Authors: Chinnaswamy, Sreedhar, Wardzynska, Aleksandra, Pawelczyk, Malgorzata, Makowska, Joanna, Skaaby, Tea, Mercader, Josep M., Ahluwalia, Tarunveer S., Grarup, Niels, Guindo-Martinez, Marta, Bisgaard, Hans, Torrents, David, Linneberg, Allan, Bønnelykke, Klaus, Kowalski, Marek L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585370/
https://ncbi.nlm.nih.gov/pubmed/28874741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10467-y
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