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Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation

Developmental genes in metazoan genomes are surrounded by dense clusters of conserved noncoding elements (CNEs). CNEs exhibit unexplained extreme levels of sequence conservation, with many acting as developmental long-range enhancers. Clusters of CNEs define the span of regulatory inputs for many im...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Harmston, Nathan, Ing-Simmons, Elizabeth, Tan, Ge, Perry, Malcolm, Merkenschlager, Matthias, Lenhard, Boris
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5585340/
https://ncbi.nlm.nih.gov/pubmed/28874668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00524-5
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