Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders

PURPOSE: Pharmacological activation of ocular surface cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels is a potential pro-secretory approach to treat dry eye disorders. We previously reported the discovery of aminophenyl-1,3,5-triazines, one of which, N-methyl-N-phenyl-6-...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Felix, Christian M., Lee, Sujin, Levin, Marc H., Verkman, Alan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2017
Témata:
Physiology and Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584707/
https://ncbi.nlm.nih.gov/pubmed/28873176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22525
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