Dabigatran ameliorates post-haemorrhagic hydrocephalus development after germinal matrix haemorrhage in neonatal rat pups

We aim to determine if direct thrombin inhibition by dabigatran will improve long-term brain morphological and neurofunctional outcomes and if potential therapeutic effects are dependent upon reduced PAR-1 stimulation and consequent mTOR activation. Germinal matrix haemorrhage was induced by stereot...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Klebe, Damon, Flores, Jerry J, McBride, Devin W, Krafft, Paul R, Rolland, William B, Lekic, Tim, Zhang, John H
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584693/
https://ncbi.nlm.nih.gov/pubmed/28155585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16684355
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