ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control

Group 2 innate lymphoid cells (ILC2s) are important effector cells driving the initiation of type 2 immune responses leading to adaptive T helper 2 (Th2) immunity. Here we show that ILC2s dynamically express the checkpoint inhibitor molecule PD-L1 during type 2 pulmonary responses. Surprisingly, PD-...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Schwartz, Christian, Khan, Adnan R., Floudas, Achilleas, Saunders, Sean P., Hams, Emily, Rodewald, Hans-Reimer, McKenzie, Andrew N.J., Fallon, Padraic G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584124/
https://ncbi.nlm.nih.gov/pubmed/28747424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170051
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