Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function

Small heat shock proteins (HSPBs) contain intrinsically disordered regions (IDRs), but the functions of these IDRs are still unknown. Here, we report that, in mammalian cells, HSPB2 phase separates to form nuclear compartments with liquid-like properties. We show that phase separation requires the d...

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Опубликовано в: :Cell Rep
Главные авторы: Morelli, Federica F., Verbeek, Dineke S., Bertacchini, Jessika, Vinet, Jonathan, Mediani, Laura, Marmiroli, Sandra, Cenacchi, Giovanna, Nasi, Milena, De Biasi, Sara, Brunsting, Jeanette F., Lammerding, Jan, Pegoraro, Elena, Angelini, Corrado, Tupler, Rossella, Alberti, Simon, Carra, Serena
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Press 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583511/
https://ncbi.nlm.nih.gov/pubmed/28854361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.018
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