Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV

Predicting vaccine efficacy remains a challenge. We used a systems vaccinology approach to identify early innate immune correlates of antibody induction in humans receiving the Ebola vaccine rVSV-ZEBOV. Blood samples from days 0, 1, 3, 7, and 14 were analyzed for changes in cytokine levels, innate i...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Rechtien, Anne, Richert, Laura, Lorenzo, Hadrien, Martrus, Gloria, Hejblum, Boris, Dahlke, Christine, Kasonta, Rahel, Zinser, Madeleine, Stubbe, Hans, Matschl, Urte, Lohse, Ansgar, Krähling, Verena, Eickmann, Markus, Becker, Stephan, Thiébaut, Rodolphe, Altfeld, Marcus, Addo, Marylyn
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Authors. 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583508/
https://ncbi.nlm.nih.gov/pubmed/28854372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.023
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