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The Pneumococcal Serotype 15C Capsule Is Partially O-Acetylated and Allows for Limited Evasion of 23-Valent Pneumococcal Polysaccharide Vaccine-Elicited Anti-Serotype 15B Antibodies

As a species, Streptococcus pneumoniae (the pneumococcus) utilizes a diverse array of capsular polysaccharides to evade the host. In contrast to large variations in sugar composition and linkage formation, O-acetylation is a subtle capsular modification that nonetheless has a large impact on capsula...

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Detalhes bibliográficos
Publicado no:Clin Vaccine Immunol
Main Authors: Spencer, Brady L., Shenoy, Anukul T., Orihuela, Carlos J., Nahm, Moon H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583466/
https://ncbi.nlm.nih.gov/pubmed/28637806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00099-17
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