Protective immunity differs between routes of administration of attenuated malaria parasites independent of parasite liver load

In humans and murine models of malaria, intradermal immunization (ID-I) with genetically attenuated sporozoites that arrest in liver induces lower protective immunity than intravenous immunization (IV-I). It is unclear whether this difference is caused by fewer sporozoites migrating into the liver o...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Haeberlein, Simone, Chevalley-Maurel, Séverine, Ozir-Fazalalikhan, Arifa, Koppejan, Hester, Winkel, Beatrice M. F., Ramesar, Jai, Khan, Shahid M., Sauerwein, Robert W., Roestenberg, Meta, Janse, Chris J., Smits, Hermelijn H., Franke-Fayard, Blandine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583236/
https://ncbi.nlm.nih.gov/pubmed/28871201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10480-1
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