Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension

Pulmonary arterial hypertension is a complication of methamphetamine use (METH-PAH), but the pathogenic mechanisms are unknown. Given that cytochrome P450 2D6 (CYP2D6) and carboxylesterase 1 (CES1) are involved in metabolism of METH and other amphetamine-like compounds, we postulated that loss of fu...

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Pubblicato in:Am J Physiol Lung Cell Mol Physiol
Autori principali: Orcholski, Mark E., Khurshudyan, Artyom, Shamskhou, Elya A., Yuan, Ke, Chen, Ian Y., Kodani, Sean D., Morisseau, Christophe, Hammock, Bruce D., Hong, Ellen M., Alexandrova, Ludmila, Alastalo, Tero-Pekka, Berry, Gerald, Zamanian, Roham T., de Jesus Perez, Vinicio A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582936/
https://ncbi.nlm.nih.gov/pubmed/28473326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00453.2016
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