Small nucleoli are a cellular hallmark of longevity

Animal lifespan is regulated by conserved metabolic signalling pathways and specific transcription factors, but whether these pathways affect common downstream mechanisms remains largely elusive. Here we show that NCL-1/TRIM2/Brat tumour suppressor extends lifespan and limits nucleolar size in the m...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tiku, Varnesh, Jain, Chirag, Raz, Yotam, Nakamura, Shuhei, Heestand, Bree, Liu, Wei, Späth, Martin, Suchiman, H. Eka. D., Müller, Roman-Ulrich, Slagboom, P. Eline, Partridge, Linda, Antebi, Adam
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5582349/
https://ncbi.nlm.nih.gov/pubmed/28853436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16083
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