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A Phase II Trial of Valproic Acid in Patients with Advanced, Radioiodine-Resistant Thyroid Cancers of Follicular Cell Origin

OBJECTIVE: Valproic acid (VA) is a histone deacetylase (HDAC) inhibitor that has antiproliferative effects on several types of cancer, including thyroid cancer. In addition, VA has been reported to upregulate the sodium-iodine symporter in thyroid cancer cells and increases radioiodine uptake in pre...

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Detalhes bibliográficos
Publicado no:Clin Endocrinol (Oxf)
Main Authors: Nilubol, Naris, Merkel, Roxanne, Yang, Lily, Patel, Dhaval, Reynolds, James C., Sadowski, Samira M., Neychev, Vladimir, Kebebew, Electron
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581405/
https://ncbi.nlm.nih.gov/pubmed/27392538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cen.13154
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