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The Randomized CRM: An Approach to Overcoming the Long-Memory Property of the CRM
The primary object of a phase I clinical trial is to determine the maximum tolerated dose (MTD). Typically, the MTD is identified using a dose-escalation study, where initial subjects are treated at the lowest dose level and subsequent subjects are treated at progressively higher dose levels until t...
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| Publicado no: | J Biopharm Stat |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5581285/ https://ncbi.nlm.nih.gov/pubmed/28340333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2017.1293076 |
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