Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping

PURPOSE: Targeting of the HER2 protein in human breast cancer represents a major advance in oncology, but relies on measurements of total HER2 protein and not HER2 signaling network activation. We utilized reverse phase protein microarrays (RPMAs) to measure total and phosphorylated HER2 in the cont...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Wulfkuhle, Julia D., Berg, Daniela, Wolff, Claudia, Langer, Rupert, Tran, Kai, Illi, Julie, Espina, Virginia, Pierobon, Mariaelena, Deng, Jianghong, DeMichele, Angela, Walch, Axel, Bronger, Holger, Becker, Ingrid, Waldhör, Christine, Höfler, Heinz, Esserman, Laura, Liotta, Lance A., Becker, Karl-Friedrich, Petricoin, Emanuel F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581198/
https://ncbi.nlm.nih.gov/pubmed/23045247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0452
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