A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer

The average survival for patients with Pancreatic Ductal Adenocarcinoma (PDA) is merely 6 months, underscoring the need for new therapeutic approaches. During PDA progression, pancreatic acinar cells lose activity of the ClassI/II bHLH factors that regulate quiescence. We previously found that promo...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Villarino, Nicholas, Signaevskaia, Lia, van Niekerk, Jaco, Medal, Rachel, Kim, Heejung, Lahmy, Reyhaneh, Scully, Kathleen, Pinkerton, Anthony, Kim, Sangwun, Lowy, Andrew, Itkin-Ansari, Pamela
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581100/
https://ncbi.nlm.nih.gov/pubmed/28881801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18587
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