A phase I trial of azacitidine and nanoparticle albumin bound paclitaxel in patients with advanced or metastatic solid tumors

BACKGROUND: Secreted protein acidic and rich in cysteine (SPARC), an albumin-binding protein, is downregulated by hypermethylation in many cancers. Hypomethylating agents such as azacitidine can upregulate SPARC in tumors, which may enhance the accumulation of albumin-bound drugs at tumor site. The...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cohen, Adam L., Ray, Abhijit, Van Brocklin, Matthew, Burnett, David M., Bowen, Randy C., Dyess, Donna L., Butler, Thomas W., Dumlao, Theresa, Khong, Hung T.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581038/
https://ncbi.nlm.nih.gov/pubmed/28881739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14183
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