Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats

BACKGROUND: Activated astrocytes release matrix metalloproteinase-2/9 (MMP-2/9) to induce central sensitization and maintain neuropathic pain. However, the mechanisms involved in the activation of MMP-2/9 on astrocytes during pain remain poorly understood. Meanwhile, there is a lack of effective tre...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Jiang, Lai, Pan, Cai-Long, Wang, Chao-Yu, Liu, Bing-Qian, Han, Yuan, Hu, Liang, Liu, Lei, Yang, Yang, Qu, Jun-Wei, Liu, Wen-Tao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580313/
https://ncbi.nlm.nih.gov/pubmed/28859670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0947-x
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