A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA

BACKGROUND: Formalin fixed paraffin embedded (FFPE) tumor samples are a major source of DNA from patients in cancer research. However, FFPE is a challenging material to work with due to macromolecular fragmentation and nucleic acid crosslinking. FFPE tissue particularly possesses challenges for meth...

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發表在:BMC Med Genomics
Main Authors: Ludgate, Jackie L., Wright, James, Stockwell, Peter A., Morison, Ian M., Eccles, Michael R., Chatterjee, Aniruddha
格式: Artigo
語言:Inglês
出版: BioMed Central 2017
主題:
Technical Advance
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580311/
https://ncbi.nlm.nih.gov/pubmed/28859641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-017-0290-1
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