Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1)

BACKGROUND: The potential mechanisms regarding how methylation of microRNA(miRNA) CpG Island could regulate cancer cell chemo-resistance remains unclear. This study aims to explore the epigenetic dysregulation mechanism of miRNA-493 and the ability to modulate lung cancer cell chemotherapy resistanc...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Principais autores: Gu, Yixue, Zhang, Zhijie, Yin, Jiang, Ye, Jiahui, Song, Yin, Liu, Hao, Xiong, Yan, Lu, Minying, Zheng, Guopei, He, Zhimin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580233/
https://ncbi.nlm.nih.gov/pubmed/28859669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0582-5
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