MEK inhibitors induce Akt activation and drug resistance by suppressing negative feedback ERK‐mediated HER2 phosphorylation at Thr701

Targeting the MEK/ERK pathway has been viewed as a promising strategy for cancer therapy. However, MEK inhibition leads to the compensatory PI3K/AKT activation and thus contributes to the desensitization of cancer cells to MEK inhibitors. The underlying molecular mechanism of this event is not yet u...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Chen, Chia‐Hung, Hsia, Te‐Chun, Yeh, Ming‐Hsin, Chen, Tsung‐Wei, Chen, Yun‐Ju, Chen, Jung‐Tsu, Wei, Ya‐Ling, Tu, Chih‐Yen, Huang, Wei‐Chien
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579385/
https://ncbi.nlm.nih.gov/pubmed/28632938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12102
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