MEK inhibitors induce Akt activation and drug resistance by suppressing negative feedback ERK‐mediated HER2 phosphorylation at Thr701

Targeting the MEK/ERK pathway has been viewed as a promising strategy for cancer therapy. However, MEK inhibition leads to the compensatory PI3K/AKT activation and thus contributes to the desensitization of cancer cells to MEK inhibitors. The underlying molecular mechanism of this event is not yet u...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Chen, Chia‐Hung, Hsia, Te‐Chun, Yeh, Ming‐Hsin, Chen, Tsung‐Wei, Chen, Yun‐Ju, Chen, Jung‐Tsu, Wei, Ya‐Ling, Tu, Chih‐Yen, Huang, Wei‐Chien
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579385/
https://ncbi.nlm.nih.gov/pubmed/28632938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12102
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados