Analysis of mutant allele fractions in driver genes in colorectal cancer – biological and clinical insights

Sequencing of tumors is now routine and guides personalized cancer therapy. Mutant allele fractions (MAFs, or the ‘mutation dose’) of a driver gene may reveal the genomic structure of tumors and influence response to targeted therapies. We performed a comprehensive analysis of MAFs of driver alterat...

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Podrobná bibliografie
Vydáno v:Mol Oncol
Hlavní autoři: Dienstmann, Rodrigo, Elez, Elena, Argiles, Guillem, Matos, Ignacio, Sanz‐Garcia, Enrique, Ortiz, Carolina, Macarulla, Teresa, Capdevila, Jaume, Alsina, Maria, Sauri, Tamara, Verdaguer, Helena, Vilaro, Marta, Ruiz‐Pace, Fiorella, Viaplana, Cristina, Garcia, Ariadna, Landolfi, Stefania, Palmer, Hector G., Nuciforo, Paolo, Rodon, Jordi, Vivancos, Ana, Tabernero, Josep
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579330/
https://ncbi.nlm.nih.gov/pubmed/28618197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12099
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