A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis

The ST2/IL33 signalling pathway has been associated with ulcerative colitis (UC). ST2, encoded by the IL1RL1 gene, is expressed as both a membrane-anchored receptor (ST2L) activated by IL33 and as a soluble receptor (sST2) with anti-inflammatory properties. In UC patients, sST2 is further increased...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Díaz-Jiménez, David, Núñez, Lucía, De la Fuente, Marjorie, Dubois-Camacho, Karen, Sepúlveda, Hugo, Montecino, Martín, Torres-Riquelme, Alejandro, García-González, Paulina, Chnaiderman, Jonás, Vossenkamper, Anna, MacDonald, Thomas T., Simian, Daniela, González, María-Julieta, Cidlowski, John A., Quera, Rodrigo, Hermoso, Marcela A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579262/
https://ncbi.nlm.nih.gov/pubmed/28860510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10465-0
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