Aggravation of acute kidney injury by mPGES-2 down regulation is associated with autophagy inhibition and enhanced apoptosis

The deletion of microsomal prostaglandin E synthase-2 (mPGES-2) does not affect in vivo PGE(2) production, and the function of this enzyme remains unknown until now. This study investigated the expression and roles of mPGES-2 in LPS induced acute kidney injury (AKI) both in vitro and in vivo. We fou...

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Pubblicato in:Sci Rep
Autori principali: Li, Ting, Liu, Ying, Zhao, Jie, Miao, Shuying, Xu, Yunfei, Liu, Ke, Liu, Meidong, Wang, Guiliang, Xiao, Xianzhong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5579259/
https://ncbi.nlm.nih.gov/pubmed/28860615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10271-8
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