GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia

An enhancer with amalgamated E-box and GATA motifs (+9.5) controls expression of the regulator of hematopoiesis GATA-2. While similar GATA-2-occupied elements are common in the genome, occupancy does not predict function, and GATA-2-dependent genetic networks are incompletely defined. A “+9.5-like”...

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Publicat a:Dev Cell
Autors principals: Hewitt, Kyle J., Katsumura, Koichi R., Matson, Daniel R., Devadas, Prithvia, Tanimura, Nobuyuki, Hebert, Alexander S., Coon, Joshua J., Kim, Jin-Soo, Dewey, Colin N., Keles, Sunduz, Hao, Siyang, Paulson, Robert F., Bresnick, Emery H.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578808/
https://ncbi.nlm.nih.gov/pubmed/28787589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.07.009
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