Genome-wide RNAi Screen for Fat Regulatory Genes in C. elegans Identifies a Proteostasis-AMPK Axis Critical for Starvation Survival

Organisms must execute metabolic defenses to survive nutrient deprivation. We performed a genome-wide RNAi screen in Caenorhabditis elegans to identify fat regulatory genes indispensable for starvation resistance. Here we show that opposing proteostasis pathways are principal determinants of starvat...

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Pubblicato in:Cell Rep
Autori principali: Webster, Christopher M., Pino, Elizabeth C., Carr, Christopher E., Wu, Lianfeng, Zhou, Ben, Cedillo, Lucydalila, Kacergis, Michael C., Curran, Sean P., Soukas, Alexander A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578715/
https://ncbi.nlm.nih.gov/pubmed/28723566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.06.068
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