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Genome-Wide RNAi Ionomics Screen Reveals New Genes and Regulation of Human Trace Element Metabolism

Trace elements are essential for human metabolism and dysregulation of their homeostasis is associated with numerous disorders. Here we characterize mechanisms that regulate trace elements in human cells by designing and performing a genome-wide high-throughput siRNA/ionomics screen, and examining t...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Malinouski, Mikalai, Hasan, Nesrin M., Zhang, Yan, Seravalli, Javier, Lin, Jie, Avanesov, Andrei, Lutsenko, Svetlana, Gladyshev, Vadim N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578452/
https://ncbi.nlm.nih.gov/pubmed/24522796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4301
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