hMYH cell cycle-dependent expression, subcellular localization and association with replication foci: evidence suggesting replication-coupled repair of adenine:8-oxoguanine mispairs

The human MutY homolog, hMYH, is an adenine-specific DNA glycosylase that removes adenines or 2-hydroxyadenines mispaired with guanines or 8-oxoguanines. In order to prevent mutations, this activity must be directed to the newly synthesized strand and not the template strand during DNA synthesis. Th...

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Εκδόθηκε σε:	Nucleic Acids Res
Κύριοι συγγραφείς:	Boldogh, Istvan, Milligan, Daun, Lee, Myung Soog, Bassett, Heather, Lloyd, R. Stephen, McCullough, Amanda K.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Oxford University Press 2001
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55773/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11433026/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.13.2802
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