Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis

Alternative C activation is involved in the pathogenesis of ANCA-associated vasculitis. However, glucocorticoids used as treatment contribute to the morbidity and mortality of vasculitis. We determined whether avacopan (CCX168), an orally administered, selective C5a receptor inhibitor, could replace...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Jayne, David R.W., Bruchfeld, Annette N., Harper, Lorraine, Schaier, Matthias, Venning, Michael C., Hamilton, Patrick, Burst, Volker, Grundmann, Franziska, Jadoul, Michel, Szombati, István, Tesař, Vladimír, Segelmark, Mårten, Potarca, Antonia, Schall, Thomas J., Bekker, Pirow
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2017
Fag:
Clinical Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576933/
https://ncbi.nlm.nih.gov/pubmed/28400446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016111179
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