Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality

Downstream metabolic events can contribute to the lethality of drugs or agents that interact with a primary cellular target. In bacteria, the production of reactive oxygen species (ROS) has been associated with the lethal effects of a variety of stresses including bactericidal antibiotics, but the r...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Takahashi, Noriko, Gruber, Charley C., Yang, Jason H., Liu, Xiaobo, Braff, Dana, Yashaswini, Chittampalli N., Bhubhanil, Sakkarin, Furuta, Yoshikazu, Andreescu, Silvana, Collins, James J., Walker, Graham C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576823/
https://ncbi.nlm.nih.gov/pubmed/28794281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707466114
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