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Molecular targeting in acute myeloid leukemia

Acute myeloid leukemia (AML) is a heterogenous disease associated with distinct genetic and molecular abnormalities. Somatic mutations result in dysregulation of intracellular signaling pathways, epigenetics, and apoptosis of the leukemia cells. Understanding the basis for the dysregulated processes...

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Bibliographic Details
Published in:J Transl Med
Main Authors: Lim, Seah H., Dubielecka, Patrycja M., Raghunathan, Vikram M.
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576374/
https://ncbi.nlm.nih.gov/pubmed/28851395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1281-x
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