Effect of Amino Acid Substitutions Within the V3 Region of HIV-1 CRF01_AE on Interaction with CCR5-Coreceptor

Specific amino acids within the V3 loop of HIV-1 CRF01_AE envelope glycoprotein that are involved in the interaction with CCR5/CXCR4 coreceptors, are not well characterized. We generated V3 mutants using polymerase chain reaction (PCR)-based site-directed mutagenesis of HIV-1 CRF01_AE R5-env plasmid...

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Detalhes bibliográficos
Publicado no:AIDS Res Hum Retroviruses
Main Authors: Hongjaisee, Sayamon, Braibant, Martine, Barin, Francis, Ngo-Giang-Huong, Nicole, Sirirungsi, Wasna, Samleerat, Tanawan
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Virology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576193/
https://ncbi.nlm.nih.gov/pubmed/28497977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2017.0044
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