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Estimation in multi‐arm two‐stage trials with treatment selection and time‐to‐event endpoint

We consider estimation of treatment effects in two‐stage adaptive multi‐arm trials with a common control. The best treatment is selected at interim, and the primary endpoint is modeled via a Cox proportional hazards model. The maximum partial‐likelihood estimator of the log hazard ratio of the selec...

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Bibliografske podrobnosti
izdano v:Stat Med
Main Authors: Brückner, Matthias, Titman, Andrew, Jaki, Thomas
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575545/
https://ncbi.nlm.nih.gov/pubmed/28612371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7367
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