Dose Finding of Lenvatinib in Subjects With Advanced Hepatocellular Carcinoma Based on Population Pharmacokinetic and Exposure–Response Analyses

Hepatocellular carcinoma (HCC) accounts for up to 90% of primary liver cancer occurrences worldwide. Lenvatinib, a multikinase inhibitor, was approved in radioiodine‐refractory differentiated thyroid cancer. In this phase 2 study (study 202), we aimed to identify the lenvatinib optimal dose for subj...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Tamai, Toshiyuki, Hayato, Seiichi, Hojo, Seiichiro, Suzuki, Takuya, Okusaka, Takuji, Ikeda, Kenji, Kumada, Hiromitsu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Pharmacometrics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575539/
https://ncbi.nlm.nih.gov/pubmed/28561918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.917
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