P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting

Nucleotide metabolism in cancer cells can influence malignant behavior and intrinsic resistance to therapy. Here we describe p53-dependent control of the rate-limiting enzyme in the pyrimidine catabolic pathway, dihydropyrimidine dehydrogenase (DPYD) and its effect on pharmacokinetics of and respons...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Gokare, Prashanth, Finnberg, Niklas K., Abbosh, Phillip H., Dai, Jenny, Murphy, Maureen E., El-Deiry, Wafik S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575263/
https://ncbi.nlm.nih.gov/pubmed/28851987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09859-x
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