TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans

In mammals, hypoxic stress management is under the control of the Hypoxia Inducible Factors, whose activity depends on the stabilization of their labile α subunit. In particular, the skeletal muscle appears to be able to react to changes in substrates and O(2) delivery by tuning its metabolism. The...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Capitanio, Daniele, Fania, Chiara, Torretta, Enrica, Viganò, Agnese, Moriggi, Manuela, Bravatà, Valentina, Caretti, Anna, Levett, Denny Z. H., Grocott, Michael P. W., Samaja, Michele, Cerretelli, Paolo, Gelfi, Cecilia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575144/
https://ncbi.nlm.nih.gov/pubmed/28852047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10097-4
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