Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential

Cardiac progenitor cells (CPCs) have been shown to promote cardiac regeneration and improve heart function. However, evidence suggests that their regenerative capacity may be limited in conditions of severe hypoxia. Elucidating the mechanisms involved in CPC protection against hypoxic stress is esse...

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Pubblicato in:Sci Rep
Autori principali: Bellio, Michael A., Pinto, Mariana T., Florea, Victoria, Barrios, Paola A., Taylor, Christy N., Brown, Ariel B., Lamondin, Courtney, Hare, Joshua M., Schulman, Ivonne H., Rodrigues, Claudia O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575078/
https://ncbi.nlm.nih.gov/pubmed/28851980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09813-x
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