Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes

Side effects on cardiac ion channels are one major reason for new drugs to fail during preclinical evaluation. Herein we propose a simple optogenetic screening tool measuring extracellular field potentials (FP) from paced cardiomyocytes to identify drug effects over the whole physiological heart ran...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Lapp, Hendrik, Bruegmann, Tobias, Malan, Daniela, Friedrichs, Stephanie, Kilgus, Carsten, Heidsieck, Alexandra, Sasse, Philipp
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575076/
https://ncbi.nlm.nih.gov/pubmed/28851973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09760-7
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker