Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: a possibility for riluzole as a prophylactic drug

Oxaliplatin, a chemotherapy medication, causes severe peripheral neuropathy. Although oxaliplatin-induced peripheral neuropathy is a dose-limiting toxicity, a therapeutic strategy against its effects has not been established. We previously reported the involvement of N-methyl-D-aspartate receptors a...

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Publicat a:Sci Rep
Autors principals: Yamamoto, Shota, Ushio, Soichiro, Egashira, Nobuaki, Kawashiri, Takehiro, Mitsuyasu, Shohei, Higuchi, Hitomi, Ozawa, Nana, Masuguchi, Ken, Ono, Yuko, Masuda, Satohiro
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574967/
https://ncbi.nlm.nih.gov/pubmed/28851920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08891-1
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