Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA Gene

Fosfomycin is a decades-old antibiotic which is being revisited because of its perceived activity against many extensively drug-resistant Gram-negative pathogens. FosA proteins are Mn(2+) and K(+)-dependent glutathione S-transferases which confer fosfomycin resistance in Gram-negative bacteria by co...

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Udgivet i:mBio
Main Authors: Ito, Ryota, Mustapha, Mustapha M., Tomich, Adam D., Callaghan, Jake D., McElheny, Christi L., Mettus, Roberta T., Shanks, Robert M. Q., Sluis-Cremer, Nicolas, Doi, Yohei
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574708/
https://ncbi.nlm.nih.gov/pubmed/28851843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00749-17
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