Anti-Apoptotic Effects of Osteopontin via the Up-Regulation of AKT/mTOR/β-Catenin Loop in Acute Myeloid Leukemia Cells

Background: The conventional chemotherapeutic regimens which applied for treatment of acute myeloid leukemia (AML) mostly target tumor bulk but not leukemic stem cells (LSCs). Aberrant expression or activation of mediators such as osteopontin (OPN) or PI3K/PTEN/Akt/mTOR pathway plays a key role in m...

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Vydáno v:Int J Hematol Oncol Stem Cell Res
Hlavní autoři: Zahed Panah, Mahdi, Nikbakht, Mohsen, Sajjadi, Seyed Mehdi, Rostami, Shahrbano, Norooznezhad, Amir Hossein, Kamranzadeh Fumani, Hosein, Ghavamzadeh, Ardeshir, Mohammadi, Saeed
Médium: Artigo
Jazyk:Inglês
Vydáno: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574411/
https://ncbi.nlm.nih.gov/pubmed/28875010
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