Crystal Structure of the DFNKF Segment of Human Calcitonin Unveils Aromatic Interactions between Phenylalanines

Although intensively studied, the high‐resolution crystal structure of the peptide DFNKF, the core‐segment of human calcitonin, has never been described. Here we report how the use of iodination as a strategy to promote crystallisation and facilitate phase determination, allowed us to solve, for the...

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Detalhes bibliográficos
Publicado no:Chemistry
Main Authors: Bertolani, Arianna, Pizzi, Andrea, Pirrie, Lisa, Gazzera, Lara, Morra, Giulia, Meli, Massimiliano, Colombo, Giorgio, Genoni, Alessandro, Cavallo, Gabriella, Terraneo, Giancarlo, Metrangolo, Pierangelo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573999/
https://ncbi.nlm.nih.gov/pubmed/27806188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201604639
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